La transmission de l’ADNmt

Table des matières

INTRODUCTION GENERALE
Fonctions mitochondriales
L’ADN mitochondrial chez les métazoaires
La transmission de l’ADNmt chez les métazoaires: une règle universelle ?
La double transmission uniparentale de l’ADNmt chez les bivalves
L’évolution moléculaire des ADNmt F et M chez les Mytilidae
« Ménage à trois» chez les moules: un génome nucléaire et deux génomes
Initochondriaux
Objectif général du projet de recherche
Objectifs spécifiques du projet de recherche
CHAPITRE l
COMPARATIVE ANAL YSIS OF GENDER-ASSOCIA TED, COMPLETE
MITOCHONDRIAL GENOMES IN MARINE MUSSELS (MYTILUS SPP.) 
Résumé
1.1 Abstract
1.2 Introduction
1.3 Materials and Methods
1.3.1 Collection, genotyping, and mitotyping of specimens
1.3.2 MtDNA amplification and sequencing protocols
1.3.3 Data analysis
1.4 Results and discussion
1.4.1 Sequence, Gene Content and Organization of Bivalve Mitochondrial
Genomes
1.4.2 Transfer RNA and Ribosomai RNA Genes
1.4.3 Noncoding Sequences
1.4.4 Comparative Analysis of Gender-Associated Mitochondrial Genomes in
Mytilid Mussels
1.4.5 Analysis of expanded cox1 data set
1.4.6 Evidence for Non-Homologous Recombination Between GenderAssociated mtDNA Lineages in Mytilus trossulus
1.4.7 The presence of two potential control regions and their implication in the
transmission dynamics of the mitochondrial genomes in blue musseis
1.4.8 The DUI System: A Network of Nuclear/Cytoplasmic Interactions
1.5 Acknowledgements
CHAPITRE II
ROLE-REVERSAL OF GENDER-ASSOCIATED MITOCHONDRIAL DNA
AFFECTS MITOCHONDRIAL FUNCTION IN MYTILUS EDULIS (BIV AL VIA:
MYTILIDAE) 
Résunlé
2.1 Abstract
2.2 Introduction
2.3 Materials and Methods
2.3.1 Experimental animaIs
2.3 .2 Mitotyping and genotyping
2.3 .3 Enzymatic assays
2.3.4 Protein assays
2.3.5 Statistical analyses
2.4 Results and Discussion
2.5 Acknowledgements
CHAPITRE III
MOLECULAR CO-EVOLUTION OF NUCLEAR- AND MITOCHONDRIALENCODED PROTEIN SUBUNITS IN A SPEClES WITH DOUBL y UNIPARENTAL INHERITANCE OF MTDNA 
Résumé
3.1 Abstract
3.2 Introduction
3.3 Materials and Methods
3.3.1 Collection and genotyping of specimens
3.3.2 Sequencing of mitochondrial genes
3.3.3 Sequencing of nuclear genes
3.3.4 Data analyses
3.4 Results
3.4.1 Mitochondrial genes
3.4.2 Nuclear genes
3.4.3 Divergence between M edulis and M galloprovincialis
3.5 Discussion
3.6 Acknowledgements
CONCLUSION GÉNÉRALE